About Us

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About Us

We are delighted to introduce the Protein Crystallography Laboratory at the University Center for Bioscience and Biotechnology, National Cheng Kung University—a facility dedicated to advancing structural biology research. Our comprehensive services support scientists at every stage of the crystallographic workflow, from protein production to structural bioinformatics applications.

Understanding protein structures is key to unraveling their functions and interactions, leading to breakthroughs in drug discovery, biotechnology, and fundamental biology. Our laboratory offers a range of services to accelerate your research, including:

Protein Production – High-quality recombinant protein expression and purification for crystallographic studies.

Crystallization Screening – Screening and optimizing conditions to obtain high-quality protein crystals.

Protein Crystal Observation – Monitoring and analyzing crystal growth to ensure optimal diffraction quality.

X-ray Diffraction Data Collection – High-resolution data acquisition using advanced beamlines at the National Synchrotron Radiation Research Center (NSRRC), Hsinchu, Taiwan.

Phase Calculation – Structure determination through Molecular Replacement (MR), Multiple Anomalous Dispersion (MAD), and Multiple Isomorphous Replacement (MIR) techniques.

Model Building – Constructing precise atomic models from diffraction data.

Structure Refinement & Validation – Refining models for accuracy and ensuring compliance with publication standards.

Structural Bioinformatics & Applications – Providing computational insights into functional mechanisms, molecular interactions, and drug target discovery.

We are committed to providing high-quality, reliable services to assist researchers, academic institutions, and industry partners in advancing structural biology research. Whether you need technical support for a single step or a complete research cooperation plan, we will fully assist you in exploring the mysteries of protein structures.

Let's push the boundaries of structural biology together!

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